Well-known is the marked antiphlogistic and pain-antagonizing activity of ketoprofen, the most effective compound in this sense amongst the synthesized nonsteroid drugs. This is the active substance of ketoprofen gel which therefore enables the topical percutaneous treatment of the painful, phlogistic or traumatic affections of the joints, the tendons, the ligaments and the muscles. It also contributes in contingent association with the proper treatments by usual route to the prompt recovery of the superficial inflammatory processes involving skin, veins, lymphatic vessels, lymph glands. A suitable excipient ensures the transcutaneous penetration of ketoprofen without provoking any systemic-like side effects; tolerability is excellent in the application site even for the most sensitive skin.