Faktu Mechanism of Action

Antihemorrhoidal.
Pharmacology: Pharmacodynamics: Mechanism of Action: Policresulen + Cinchocaine HCl (Faktu) has multiple actions predominantly attributable to Policresulen. It arrests to bleeding by coagulating blood protein and inducing the muscle fibers of small blood vessels to contract. The coagulating properties and the acid pH brings out the antimicrobial action against Escherichia coli, staphylococci, and streptococci, Pseudomonas aeruginosa, Proteus vulgaris, candida and other bacteria. Thus, the wound is protected against infection. In vitro periodic investigations on the different pathogens have revealed no change in sensitivity. The coagulation of necrotic and pathologically altered tissues cleans the wound and promotes wound healing. Cinchocaine has local anesthetic action which relieves pain and itching. The main active ingredient of Policresulen, is a high molecular organic acid with selective protein-precipitating properties. The pH of the Policresulen and Cinchocaine hydrochloride product is 4.0. Policresulen coagulates necrotic or pathologically altered tissue in anorectal conditions and expels this from the body. Healthy tissue surrounding the affected area is unaffected. Policresulen acts as a local haemostatic to coagulate blood protein and cause a contraction of the small blood vessels. This means that bleeding in the anal canal and in the perianal region is quickly controlled. At the same time, policresulen induces reactive hyperaemization at the affected area, thereby stimulating healing and promoting reepithelialization. In addition, the antiseptic effect of policresulen prevents secondary infection of the anorectal wound region. In this way, inflammation is prevented. Weeping, a common accompanying symptom of haemorrhoids, is prevented by the astringent properties of policresulen. Cinchocaine, a proven topical anaesthetic, reversibly and locally restricts the sensitivity and capacity of sensory nerves. Pain and itching, common symptoms of anorectal conditions are thus eliminated. The combination of the two ingredients policresulen and cinchocaine rapidly eliminates bleeding, pain, itching and weeping, prevents inflammation and promotes the regeneration of the affected tissue.
Pharmacokinetics: General pharmacokinetics: After oral administration of policresulen about 10% of the dose was absorbed in animal experiments. The absorption after local intravaginal or intrarectal application was slightly less with 6-8%. Absorbed policresulen constituents were eliminated with a half-life between 4 and 5 hours. No biotransformation was detected. Intravenously administered policresulen was eliminated mainly via urine, and less than 10% were excreted through feces, whereas orally or rectally administered drug was excreted mainly in the feces due to its low absorption, and less than 10% were eliminated via urine. After dermal application of cinchocaine, 15.3% of the applied dose was absorbed by rats within 12 h. The terminal elimination half-life of the unchanged drug was 12 min after intraperitoneal administration in rats. The drug is largely metabolised by different species and excreted in urine and bile in nearly equal amounts by rats. Because of these findings and based on long-term human experience only minor amounts are expected to be absorbed after local administration on skin and mucous membranes.