Ezetrol Dosage/Direction for Use

The patient should be on an appropriate lipid-lowering diet and should continue on this diet during treatment with Ezetimibe (EZETROL).
Use in Patients with Primary Hypercholesterolemia: The recommended dose of Ezetimibe (EZETROL) is 10 mg once daily, used alone, with a statin, or with fenofibrate. Ezetimibe (EZETROL) can be administered at any time of the day, with or without food.
Use in Patients with Coronary Heart Disease: Combination Therapy with a Statin: For incremental cardiovascular event reduction in patients with coronary heart disease, Ezetimibe (EZETROL) 10 mg may be administered with a statin with proven cardiovascular benefit.
Use in Patients with Renal Impairment/Chronic Kidney Disease: Monotherapy: In patients with renal impairment, no dosage adjustment of Ezetimibe (EZETROL) is necessary.
Combination Therapy with Simvastatin: In patients with mild renal impairment (estimated GFR ≥60 mL/min/1.73 m²), no dosage adjustment of Ezetimibe (EZETROL) or simvastatin is necessary. In patients with chronic kidney disease and estimated glomerular filtration rate <60 mL/min/1.73 m², the dose of Ezetimibe (EZETROL) is 10 mg and the dose of simvastatin is 20 mg once a day in the evening. In such patients, the use of higher doses of simvastatin should be closely monitored (see Precautions).
Use in the Elderly: No dosage adjustment is required for elderly patients.
Use in Pediatric Patients: Children and adolescents ≥6 years: No dosage adjustment is required.
Children <6 years: Treatment with Ezetimibe (EZETROL) is not recommended.
Use in Hepatic Impairment: No dosage adjustment is required in patients with mild hepatic insufficiency (Child-Pugh score 5 to 6). Treatment with ezetimibe is not recommended in patients with moderate (Child-Pugh score 7 to 9) or severe (Child-Pugh score >9) liver dysfunction (see Precautions).
Co-administration with bile acid sequestrants: Dosing of Ezetimibe (EZETROL) should occur either ≥2 hours before or ≥4 hours after administration of a bile acid sequestrant.