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Drugs known to induce the hepatic CYP450-3A4 such as barbiturates, anti-epileptic agents (phenytoin, carbamazepine), rifampicin, phenylbutazone, spironolactone, griseofulvin, some antibiotics (ampicillins, tetracyclines) and also herbal products containing St. John's wort [Hypericum perforatum] may increase metabolism and the elimination of progesterone.
Ketoconazole and other inhibitors of CYP450-3A4 may increase bioavailability of progesterone. Progesterone may affect the results of laboratory tests of hepatic and/or endocrine functions.
Progestogens may decrease glucose tolerance and thus, may increase insulin resistance or resistance to any other antidiabetic agents used in patients with diabetes mellitus.
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