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Lynestrenol (Exluton) should not be used during pregnancy. If a pregnancy occurs, Lynestrenol (Exluton) treatment should be stopped immediately. Animal studies have shown that very high doses of progestogenic substances may cause masculinization of female foetuses.
Extensive epidemiological studies have revealed neither an increased risk of birth defects in children born to women who used OCs prior to pregnancy, nor a teratogenic effect when OCs were taken inadvertently during early pregnancy. Although this probably also applies to all OCs, it is not clear whether this is also the case for Lynestrenol (Exluton).
Similar to other progestogen-only contraceptives, Lynestrenol (Exluton) does not influence the production or the quality of breast milk, but a small amount of progestogen is excreted in the breast milk. The amount of lynestrenol and metabolites excreted in the milk is about 0.14% of the daily administered dose, but no adverse effects on infant growth and development have been reported.
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