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Few cases of overdose have been reported with some patients experiencing mild to moderate symptoms with doses above 200 mg. Clinical features of betahistine overdose may include nausea, dry mouth, vomiting, dyspepsia, abdominal pain, headache, somnolence, hypotension, itching; convulsion, pulmonary or cardiac complications, ataxia, and seizures at higher doses. A case of convulsion was reported at a dose of 728 mg.
There is no specific antidote to betahistine overdose; gastric lavage and symptomatic treatment are recommended.
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