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Known hypersensitivity to amlodipine, valsartan, HCTZ, other sulfonamide derived medicinal products or to any of the excipients.
Pregnancy (see USE IN PREGNANCY & LACTATION).
Contraindicated in patients with anuria because of hydrochlorothiazide component.
Concomitant use of angiotensin receptor antagonists (ARBs) - including valsartan - or of angiotensin-converting enzyme inhibitors (ACEIs) with aliskiren in patients with Type 2 diabetes (see Dual blockade of the RAS under INTERACTIONS).
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