IV Adult 70 kg Initially 10-20 mL/hr (0.16-0.33 mL/min) equiv to 0.4-0.8 mg/hr noradrenaline base (0.8 mg-1.6 mg/hr noradrenaline tartrate); or 5 mL/hr (0.08 mL/min) equiv to 0.2 mg/hr noradrenaline base (0.4 mg/hr noradrenaline tartrate). Titrate dose in steps of 0.05-0.1 mcg/kg/min noradrenaline base according to the effect observed. Continue for as long as vasoactive support is indicated.
Extravasation may cause local tissue necrosis; stop infusion & infiltrate area w/ phentolamine w/o delay if extravasation occurs. Patients w/ coronary, mesenteric or peripheral vascular thrombosis; hypotension following MI, Prinzmetal's variant angina, diabetes, HTN or hyperthyroidism; patients who exhibit profound hypoxia or hypercarbia. Frequently check BP & flow rate to avoid HTN. Prolonged administration may result in plasma vol depletion. Patients on controlled Na diet. May impair placental perfusion & induce fetal bradycardia. May exert contractile effect on pregnant uterus & lead to fetal asphyxia in late pregnancy. Not recommended in childn. Elderly.
C01CA03 - norepinephrine ; Belongs to the class of adrenergic and dopaminergic cardiac stimulants excluding glycosides. Used in the treatment of hypotension.
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