Evatocin Dosage/Direction for Use

Dosage of Oxytocin is determined by uterine response. The following dosage information is based upon the various regimens and indications in general use.
Induction or stimulation of labour: Intravenous infusion (drip method) is the only acceptable method of administration for the induction or stimulation of the labour. Accurate control of the rate of infusion flow is essential. An infusion pump or other such device and frequent monitoring of strength of contractions and fetal heart rate are necessary for the safe administration of Oxytocin for the induction or stimulation of labour. If uterine contractions become too powerful the infusion can be abruptly stopped, and Oxytocin stimulation of the uterine musculature will soon wane.
An intravenous infusion of non-Oxytocin containing solution should be started. Physiologic electrolyte solution should be used except under unusual circumstances.
To prepare the usual solution for infusion, the contents of Oxytocin injection equivalent to 10 units are combined aseptically with 1000 mL of nonhydrating diluent. The combined solution, rotated in the infusion bottle to ensure thorough mixing contains 10 mU/mL. Add the container with diluted Oxytocin solution to the system through use of constant infusion pump or other such device, to control accurately the rate of infusion.
The initial dose should not be more than 1-2 mU/minute. The dose may be gradually increased in increments of no more than 1-2 mU/minute until a contraction pattern has been established, which is similar to normal labour.
The fetal heart rate, resting uterine tone, the frequency, duration, and force of contractions should be monitored.
The oxytocin infusion should be discontinued immediately in the event of uterine hyperactivity or fetal distress. Oxygen should be administered to the mother. A responsible physician must evaluate the mother and the fetus.
Control of postpartum uterine bleeding: Intravenous infusion (Drip method): To control postpartum bleeding, 10-40 units of Oxytocin may be added to 1000 mL of a non-hydrating diluent and run at a rate necessary to control uterine atony.
Intramuscular administration: 10 units of Oxytocin can be given after delivery of the placenta.
Treatment of Incomplete or inevitable abortion: Intravenous infusion with physiologic saline solution, 500 mL or 5% dextrose in physiologic saline solution to which 10 units of Oxytocin have been added should be infused at rate of 20-40 drops per minute.