Euthyrox Overdosage

Symptoms: Overdose may cause symptoms of a significant increase in the metabolic rate. If a higher dose than prescribed is taken, symptoms such as rapid heart rate (tachycardia), anxiety, agitation or unintended movements (hyperkinesia) may occur. In patients with a neurological disorder (e.g. epilepsy), seizures may occur in isolated cases. If any of this happens, the patient should contact the doctor immediately.
Several cases of sudden cardiac death have been reported in patients with long years of levothyroxine abuse.
In predisposed patients isolated cases of seizures have been reported when the individual dose tolerance limit was exceeded. Overdose of levothyroxine may result in hyperthyroidism and could lead to symptoms of acute psychosis, especially in patients at risk of psychotic disorders.
Management: An elevated T3 level is a reliable indicator of overdose, more than elevated T4 or fT4 levels. Depending on the extent of the overdosage, it is recommended that treatment is interrupted and that tests are carried out.
Beta-sympathomimetic effects such as tachycardia, anxiety, agitation or hyperkinesia can be relieved by beta-blockers. After extreme doses, plasmapheresis may be indicated.