Drugs that have interactions with bupivacaine includes: Beta-adrenergic blockers: May enhanced sympathomimetic effects when used with bupivacaine.
Chloroprocaine: May lessen bupivacaine's action with Chloroprocaine.
Cyclic antidepressants and MAOIs: Can cause severe sustained hypertension when used with bupivacaine.
Enflurane, halothane, Isoflurane and related drugs: It can cause arrhythmias when used with bupivacine.
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