Esmeron Caution For Usage

Incompatibilities: Physical incompatibility has been documented for Rocuronium Bromide (Esmeron) when added to solutions containing the following drugs: amphotericin, amoxicillin, azathioprine, cefazolin, cloxacillin, dexamethasone, diazepam, enoximone, erythromycin, famotidine, frusemide, hydrocortisone sodium succinate, insulin, methohexital, methylprednisolone, prednisolone sodium succinate, thiopental, trimethoprim and vancomycin. Rocuronium Bromide (Esmeron) is also incompatible with Intralipid.
Rocuronium Bromide (Esmeron) must not be mixed with other medicinal products except those mentioned in Special precautions for disposal and other handling.
If Rocuronium Bromide (Esmeron) is administered via the same infusion line that is also used for other drugs, it is important that this infusion line is adequately flushed (e.g. with 0.9% NaCl) between administration of Rocuronium Bromide (Esmeron) and drugs for which incompatibility with Rocuronium Bromide (Esmeron) has been demonstrated or for which compatibility with Rocuronium Bromide (Esmeron) has not been established.
Special precautions for disposal and other handling: Compatibility studies with the following infusion fluids have been performed: In nominal concentrations of 0.5 mg/ml and 2.0 mg/ml Rocuronium Bromide (Esmeron) has been shown to be compatible with: 0.9% NaCl, 5% dextrose, 5% dextrose in saline, sterile water for injections, Lactated Ringers and Haemaccel. Administration should be begun immediately after mixing, and should be completed within 24 hours. Unused solutions should be discarded.