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Adapalene + Benzoyl Peroxide (Epiduo/Epiduo Forte) is for once-daily cutaneous use only.
In case of accidental ingestion, appropriate symptomatic measures should be taken.
Activated charcoal may be administered to aid in the removal of unabsorbed drug. General supportive measures are recommended.
Acute overdosage with the topical use is unlikely. If the medications are applied excessively, no more rapid or better results will be obtained and marked redness, peeling or discomfort may occur.
The acute oral toxicity of adapalene topical gel, 0.1% in mice and rats is greater than 10 mL/kg (10 mg/kg). Inadvertent oral ingestion of adapalene may lead to the same adverse effects as those associated with excessive oral intake of Vitamin A, including teratogenesis in women of childbearing years. Therefore, pregnancy testing should be carried out in women of childbearing potential who have ingested the product.
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