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Hypersensitivity to the active substances or to any of the excipients listed in Description.
Use with strong P-gp and strong CYP inducers: Medicinal products that are strong P-glycoprotein (P-gp) and/or strong cytochrome P450 (CYP) inducers (carbamazepine, phenobarbital, phenytoin, rifampicin, rifabutin and St. John's wort). Co-administration will significantly decrease sofosbuvir or velpatasvir plasma concentrations and could result in loss of efficacy of sofosbuvir/velpatasvir (see Interactions).
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