Management of nausea & vomiting by cytotoxic chemotherapy & radiography in less emetogenic chemotherapy & radiotherapy Adult Slow IV/IM 8 mg immediately before treatment. To be followed by 8 mg orally after 12 hr.
Prevention of delayed emesis Orally 8 mg bid up to 5 days.
Highly emetogenic chemotherapy Slow IV/IM 8 mg immediately before chemotherapy, followed by 2 IV doses of 8 mg 2-4 hr apart, as needed by a constant infusion of 1 mg/hr for up to 24 hr. Alternatively, a single dose of 32 mg diluted in 50-100 mL of saline or other compatible infusion fluid infused over 15 min immediately before chemotherapy.
Prevention of delayed emesis Continue orally 8 mg bid up to 5 days after a course of chemotherapy.
Childn IV 5 mg/m
2 for 15 min immediately before chemotherapy followed by 4 mg orally every 12 hr or bid continued for up to 5 days after a course of treatment.
Prevention of post-op nausea & vomiting Adult 16 mg orally 1 hr prior to anaesth or 8 mg 1 hr prior to anesth followed by 2 further doses of 8 mg at 8-hr intervals. Alternatively, 4 mg single dose slow IV inj at induction of anaesth.
Childn IV 0.1 mg/kg. Max: 4 mg.
Treatment of post-op nausea & vomiting Adult Slow IV 4 mg as a single dose.
Childn Slow IV 0.1 mg/kg as a single dose before, during or after anesth. Max: 4 mg.
Hepatic impairment Max: 8 mg daily.
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