Elixime Dosage/Direction for Use

Tab: Usual oral doses for adults are 125 mg twice daily for uncomplicated urinary-tract infections and 250 to 500 mg twice daily for respiratory tract infections. A dose for children more than 3 months of age is 125 mg twice daily or 10 mg per kg body weight twice daily to a maximum of 250 mg daily. Children over 2 years of age with otitis media may be given 250 mg twice daily or 15 mg per kg twice daily to a maximum of 500 mg daily. Or as prescribed by a Physician.
Powd for inj: Adults: Administer i.m. or i.v. 750 mg (potency) of cefuroxime sodium three times a day. In severe cases, administer i.m. up to 1.5 g (potency) three times a day.
The frequency of i.m. or i.v. injections can be increased to four times if necessary, giving total doses of 3 g to 6 g daily.
Infants and children: Administer i.m. or i.v. 30~100 mg (potency)/kg/day in three or four divided doses. Usually appropriate doses are recommended to 60 mg (potency)/kg/day.
Neonates: Administer i.m. or i.v. 30~100 mg (potency)/kg/day in three or four divided doses. Since in case of neonate during 1 week after their birth half-life of cefuroxime in serum may be prolonged 3-5 times to adults, it should be carefully administered.
Gonorrhea: Administer i.m. 1.5 g (potency) once or 1.5 g (potency) injection may be equally divided between two gluteal injection sites.
Patients with impaired renal function: It is not necessary to adjust the dose in patients with slight impaired renal function. However, in patient with marked impairment (creatinine clearance: 10-20 mL/min), the daily dose is recommended to 750 mg (potency) twice and with severe impairment (creatinine clearance ≤10 mL/min) 750 mg (potency) once daily is adequate. For patients on haemodialysis a further 750 mg (potency) dose should be given at the end of each dialysis. For patients on continuous arteriovenous haemodialysis or high-flux haemofiltration a suitable dosage is 750 mg (potency) twice a day. For low-flux haemofiltration follow the dosage recommended under impaired renal function.
Postoperative prophylaxis of infections: Abdominal, pelvic and orthopedic operations: The usual dose is 1.5 g i.v. with induction of anesthesia. It may be supplemented with two 750 mg (potency) i.m. doses eight and sixteen hours later.
Cardiac, pulmonary, esophageal, and vascular operations: The usual dose is 1.5 g (potency) cefuroxime powder may be mixed with each pack of methyl methacrylate cement polymer before adding the liquid monomer.
Meningitis: Adults: Administer q.v. 3 g (potency) three times a day.
Infants and children: Administer i.v. 200-240 mg (potency) in three or four divided doses a day. This dosage may be reduced to 100 mg (potency)/kg/day after three days or when clinical improvement occurs.
Neonates: The initial dosage should be 100 mg (potency)/kg/day i.v. A reduction to 50 mg (potency)/kg/day may be made when clinical improvement occurs.
Preparation of injectable solution: 250 mg (potency) is dissolved in 2 mL, and 750 mg (potency) in 6 mL, and 1.5 (potency) in 15 mL sterile water for injection and injected. In case of i.v. drip infusion, 1.5 (potency) is dissolved in 50 mL sterile water for injection and the infusion should last at least 30 minutes. It is desirable not to use sodium bicarbonate solution as diluent.