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Pre-existing hypotension: If the blood pressure is already low, e.g. below 100 mmHg systolic, it must be borne in mind that the administration of isoxsuprine will, in most instances, bring about a further reduction in the blood pressure.
Prolonged premature rupture of membranes: If fetal membranes are ruptured/dilatation is >4 cm, chances of success are less. In the cases of prolonged premature rupture of membranes, the possible benefits to be gained from delaying emptying of the uterus must be weighed against the possibility that undue prolongation of the pregnancy may actually increase the maternal and fetal hazards.
Isoxsuprine should not be used in the presence of hemorrhage.
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