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Cytochrome P450 3A Inhibitors: Dutasteride is extensively metabolized in humans by the CYP3A4 and CYP3A5 isoenzymes. Because of the potential for drug-drug interactions, use caution when prescribing Dutasteride to patients taking potent, chronic CYP3A4 enzyme inhibitors (e.g., ritonavir).
Calcium Channel Antagonists: Coadministration of verapamil or diltiazem decreases Dutasteride clearance and leads to increased exposure to Dutasteride. The change in Dutasteride exposure is not considered to be clinically significant. No dose adjustment is recommended.
Cholestyramine: Administration of a single 500-mcg dose of Dutasteride followed 1 hour later by 12 g of cholestyramine does not affect the relative bioavailability of Dutasteride.
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