Adverse effects reported most frequently with pantoprazole have been headache, diarrhea and skin rashes: they have sometimes been severe enough to require discontinuation of treatment. Other effects include pruritus: fatigue, constipation, nausea and vomiting, flatulence, abdominal pain, arthralgia and myalgia, urticaria and dry mouth.
Pantoprazole may also increase the risk of gastrointestinal infections because of their acid suppressive effects.