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Pharmacology: Cefadroxil is rapidly and almost completely absorbed from the gastrointestinal tract. The rate of absorption is unaffected by food. Peak serum concentration 16 and 28 mg/mL are attained within 1-2 hrs after a single 500-mg and 1000-mg oral dose, respectively. The serum t½ of cefadroxil is 1-2 hrs in adults with normal renal function and prolonged in patients with impaired renal function. Cefadroxil is excreted unchanged about 70-90% within 24 hrs. Renal elimination of cefadroxil is substantially reduced in patients with impaired renal function. In vitro test demonstrates that the cephalosporins are bactericidal because of their inhibition of cell wall synthesis.
Sensitive gram-positive organisms are: Penicillinase and staphylococcus which do not produce penicillinase; group A β-hemolytic streptococci, Streptococcus pneumoniae and Streptococcus pyogenes.
Sensitive gram-negative organisms are: E. coli, Klebsiella pneumoniae and some strains of P. mirabilis and Haemophilus influenzae.
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