Doxyclen Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Warnings Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing Brand Resources

Concise Prescribing Info

Contents

Doxycycline hyclate

Indications/Uses

Treatment of rocky mountain spotted fever, typhus fever & typhus group, Q fever, rickettsial pox & tick fevers caused by Rickettsiae; resp tract infections; lymphogranuloma venereum; psittacosis; trachoma; inclusion conjunctivitis; uncomplicated urethral, endocervical or rectal infections in adult; nongonococcal urethritis; relapsing fever. Treatment of infections caused by gm -ve microorganisms: Chancroid, plague, tularemia, cholera, Campylobacter fetus infections, brucellosis in conjunction w/ streptomycin, bartonellosis, granuloma inguinale. Treatment of infections caused by E. coli, Enterobacter aerogenes, Shigella spp, Acinetobacter spp, resp tract infections caused by H. influenzae; resp tract infections & UTI caused by Klebsiella spp; upper resp tract infections caused by S. pneumoniae; anthrax. Alternative treatment of uncomplicated gonorrhea, syphilis, yaws, listeriosis, Vincent's infection, actinomycosis, infections caused by Clostridium spp. Adjunct to amebicides; severe acne.

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Dosage/Direction for Use

Adult 200 mg on the 1st day of treatment (administered 100 mg every 12 hr) followed by maintenance dose of 100 mg/day. Chronic infections of urinary tract 100 mg every 12 hr. Childn <45 kg w/ anthrax, rocky mountain spotted fever 2.2 mg/kg every 12 hr. ≥45 kg Adult dose. Childn w/ less severe disease >8 yr & <45 kg 4.4 mg/kg in 2 divided doses on the 1st day of treatment followed by maintenance dose of 2.2 mg/kg. Uncomplicated gonococcal infections in adults (except anorectal infections in men) 100 mg bid for 7 days. As an alternative single dose, administer 300 mg stat followed in 1 hr by a 2nd 300 mg dose. Uncomplicated urethral, endocervical or rectal infection in adults caused by C. trachomatis, nongonococcal urethritis (NGU) caused by C. trachomatis or U. urealyticum 100 mg bid for 7 days. Syphilis (early) 100 mg bid for 2 wks. Syphilis >1 yr duration 100 mg bid for 4 wks. Acute epididymo-orchitis caused by N. gonorrhoeae & C. gonorrhoeae 100 mg bid for 10 days. Prophylaxis of malaria Adult 100 mg daily, childn >8yr 2 mg/kg once daily up to the adult dose. Prophylaxis should begin 1-2 days before travel to the malarious area. Should be continued daily during travel in the malarious area & 4 wks after the traveller leaves the malarious area. Inhalational anthrax (post-exposure) Adult 100 mg bid for 60 days, childn ≥45 kg Adult dose, <45 kg 2.2 mg/kg bid for 60 days.

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Overdosage

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Administration

May be taken with or without food.

Contraindications

Hypersensitivity to tetracyclines.

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Warnings

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Special Precautions

May result to overgrowth. Discontinue if superinfection, phototoxicity occurs. May increase incidence of vag candidiasis. Diarrhea. Pregnancy & lactation. Child <8 yr.

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Use In Pregnancy & Lactation

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Adverse Reactions

Anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, inflammatory lesions (w/ monilial overgrowth) in the anogenital region, pancreatitis; hepatotoxicity (rarely); permanent tooth discoloration & enamel hypoplasia when used during tooth development. TEN, SJS, erythema multiforme, skin hyperpigmentation, maculopapular & erythematous rashes; exfoliative dermatitis; photosensitivity. Rise in BUN. Hypersensitivity including urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, serum sickness, pericarditis, exacerbation of SLE, DRESS, Jarisch-Herxheimer reaction. Hemolytic anemia, thrombocytopenia, neutropenia & eosinophilia. Bulging fontanels in infants & intracranial HTN in adults.

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Drug Interactions

Decrease plasma prothrombin w/ anticoagulants. May interfere w/ the bactericidal action of penicillin. Impaired absorption w/ antacids containing Al, Ca or Mg & Fe-containing prep; bismuth subsalicylate. Decrease t_½ w/ barbiturates, carbamazepine & phenytoin. Fatal renal toxicity w/ methoxyflurane. May render OC less effective. False elevations of urinary catecholamine levels w/ fluorescence test.

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Storage

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Description

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Action

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MIMS Class

Tetracyclines

ATC Classification

J01AA02 - doxycycline ; Belongs to the class of tetracyclines. Used in the systemic treatment of infections.

Regulatory Classification

Presentation/Packing

Form

Doxyclen cap 100 mg

Packing/Price

100's

Doxyclen

doxycycline

Manufacturer:

Lloyd

Distributor:

Nurturemed