Doxopro Mechanism of Action

Pharmacology: Pharmacokinetics: The half-life of Doxofylline is greater than 6 hours; so, this allows effective constant plasma levels with a thrice a day dose regimen. Single dose pharmacokinetic studies in humans after oral administration defined distribution and absorption of the drug. After administration, peak plasma levels are reached after 1 hour. Absolute bioavailability is about 62.6%; at pH 7.4, plasma proteins binding the compound are about 48%. Less than 4% of an orally administered dose is excreted unchanged in the urine. Doxofylline is almost completely metabolized in the liver (90% of the total drug clearance). Hydroxyethyltheophylline is the only detectable circulating metabolite of Doxofylline. After repeated administration, Doxofylline reaches the steady state in about 4 days; the elimination half-life during long-term treatment is 8-10 hours: this vaccine may decrease the hepatic clearance of xanthenes, causing an increase in blood levels. No evidence of a relationship between Doxofylline serum concentration and toxic events has been reported.