Doxokem Contraindications

Hypersensitivity to its components, acute myocardial infraction, hypotension, and in lactating women. Doxofylline must be used with caution in patients with hypertension, heart disease, hyperthyroidism, chronic right ventricular disease, congestive heart failure, liver diseases, renal diseases, in those with a history of peptic ulcer, and in the elderly.
Severe arrhythmias and seizure could be the first signs of potential overdose. Plasma concentration in doxofylline should be monitored in patients with liver disease, congestive heart failure and concomitant intake of certain drugs (erythromycin, troleandomycin, lincomycin, allopurinol, cimetidine, propranolol, and antiflu vaccine. In these cases a lower dose of doxofylline is needed Phenytoin, other anticonvulsants and smoking may cause an increase in clearance with a shorter mean half life. In these cases higher doses of doxofylline may be required.