Doxofree Special Precautions

Use with caution in patients with hypertension, heart disease, hypoxaemia, hyperthyroidism, chronic right ventricular failure, congestive heart failure, liver disease, renal disease, in those with history of peptic ulcer, and in the elderly.
Frequently, patients with congestive heart failure have markedly prolonged drug plasma levels following discontinuation of the drug.
The half-life of xanthine derivatives is influenced by a number of known variables. It may be prolonged in patients with liver disease, in patients with congestive heart failure, in those affected with Chronic Obstructive Pulmonary Disease (COPD) or concomitant infections, and in those patients taking certain other drugs (erythromycin, troleandomycin, lincomycin and other antibiotics of the same group, allopurinol, cimetidine, propranolol and anti-flu vaccine). In these cases, lower dose of Doxofylline (Doxofree) may be needed.
Use with caution in patients with hypoxemia, hyperthyroidism, liver disease, renal disease, in those with history of peptic ulcer and in elderly. Frequently, patients with Congestive Heart Failure (CHF) have markedly prolonged drug serum levels following discontinuation of doxofylline. Laboratory monitoring of plasma concentration of Doxofylline (Doxofree) is recommended in all the previously mentioned situations.