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Because tetracyclines depress plasma prothrombin activity, patients who are on anticoagulant therapy may require reduction of their anticoagulant dosage.
Since bacteriostatic drugs interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracyclines in conjunction with penicillin.
Absorption of tetracyclines is impaired by bismuth subsalicylate and antacids containing aluminum, calcium, or magnesium and iron-containing preparations.
Barbiturates, carbamazepine and phenytoin decrease the half-life of doxycycline.
Concurrent use of tetracycline and methoxyflurane has been reported to result in fatal renal toxicity. Concurrent use of tetracycline may render oral contraceptives less effective.
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