Dopezil Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Donepezil HCl

Indications/Uses

Mild, moderate & severe Alzheimer's disease; vascular dementia (dementia associated w/ cerebrovascular disease); dementia w/ Lewy bodies (DLB).

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Dosage/Direction for Use

Adult & elderly Initially 5 mg once daily in the evening for at least 1 mth. May be increased up to a max of 10 mg once daily.

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Overdosage

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Administration

May be taken with or without food.

Contraindications

Hypersensitivity to donepezil HCl or piperidine derivatives.

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Special Precautions

Patients w/ & w/o known underlying cardiac conduction abnormalities; history of asthma or obstructive pulmonary disease. Monitor closely for symptoms of active or occult GI bleeding, particularly those at increased risk for developing ulcers. Neuroleptic malignant syndrome. Rhabdomyolysis. Caution in patients w/ risk of aggression. Succinylcholine-type muscle relaxation during anesth. Bladder outflow obstruction. May impair ability to drive or operate machinery. Renal & hepatic impairment. Pregnancy & lactation. Elderly.

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Use In Pregnancy & Lactation

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Adverse Reactions

Asthenia, fungal infection, flu syndrome, malaise, sepsis, face edema, hernia, fever, back pain, pain, headache, infection, accident; CV, nervous system, GI, hematologic, musculoskeletal, metabolic/nutritional, resp, hepatic, skin & appendages, urogenital/reproductive & special senses effects.

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Drug Interactions

Inhibited metabolism w/ inhibitors of CYP3A4 (eg, ketoconazole, itraconazole, erythromycin) & CYP2D6 (eg, quinidine, fluoxetine). Increased rate of elimination w/ CYP2D6 & CYP3A4 inducers (eg, phenytoin, carbamazepine, dexamethasone, rifampicin, & phenobarb). Potential to interfere activity w/ anticholinergics. Synergistic effect w/ cholinomimetics & other cholinesterase inhibitors.

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Storage

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Description

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Action

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MIMS Class

Neurodegenerative Disease Drugs

ATC Classification

N06DA02 - donepezil ; Belongs to the class of anticholinesterases. Used in the management of dementia.

Regulatory Classification

Presentation/Packing

Form

Dopezil FC tab 10 mg

Packing/Price

30's (P2,655.99/box, P88.53/film-coated tab)

Form

Dopezil FC tab 5 mg

Packing/Price

30's (P66.9/film-coated tab, P2,006.98/box)

Dopezil

donepezil

Manufacturer:

UNILAB, Inc

Distributor:

UNILAB, Inc