Docetax Use In Pregnancy & Lactation

Use in Pregnancy: Docetaxel can cause fetal harm when administered to a pregnant woman based on its mechanism of action and findings in animals. In animal studies of rabbits and rats, docetaxel has been shown to be both embryotoxic and fetotoxic and reduce fertility in rats.
There are no adequate and well-controlled studies in pregnant women using docetaxel. If docetaxel is used during pregnancy, or if the patient becomes pregnant while receiving this drug, the patients should be informed of the potential hazard to the fetus. Women of childbearing potential should be advised to avoid becoming pregnant during therapy with docetaxel.
Use in Lactation: Docetaxel is lipophilic but it is not known whether it is distributed into human milk. Breastfeeding must be discontinued for the duration of docetaxel therapy because of the potential for adverse reactions in breastfeeding infants.
Females and Males of Reproductive Potential: During treatment with docetaxel, an effective method of contraception should be used.