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There was no evidence of drug interaction in clinical studies in which dobutamine hydrochloride injection was administered concurrently with other drug, including digitalis preparations, furosemide, spironolactone, lidocaine, glyceryl trinitrate, isosorbide dinitrate, morphine, atropine, heparin, protamine, potassium chloride, folic acid, and acetaminophen. Preliminary studies indicate that the concomitant use of dobutamine and nitroprusside results in a higher cardiac output and usually, a lower pulmonary wedge pressure that when either drug is used alone.
Beta-adrenergic blocking agents antagonize the cardiac effects of dobutamine resulting in predominance of alpha-adrenergic effects and increased peripheral resistance.
In patients on general anaesthetics (halothane, cyclopropane), usual dose of dobutamine may cause ventricular arrhythmias.
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