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Antibacterials: Raised valproate blood concentrations and symptoms consistent with valproate toxicity have been reported in a patient also given erythromycin.
Antidepressant: May antagonize the antiepileptic activity of valproate by lowering the convulsive threshold.
Gastrointestinal: Use with an antacid (aluminum and magnesium hydroxides) significantly increased the bioavailability of a valproic acid preparation in healthy subjects. Use of highly protein bound drugs with valproate may increase free valproate plasma concentrations.
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