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Indications and Dosage
Ophthalmic
Dry eye Adult: As 3% ophthalmic solution: Instil 1 drop into the affected eye(s) 6 times daily.
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What are the brands available for Diquafosol in Philippines?
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Special Precautions
Pregnancy and lactation.
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Adverse Reactions
Eye disorders: Eye irritation, eye pain, eye itching, ocular discomfort, blurred vision, conjunctival hyperaemia, eye discharge, increased lacrimation, dry eye syndrome, foreign body sensation in eyes, subconjunctival haemorrhage, photophobia, blepharitis.
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Action
Description:
Mechanism of Action: Diquafosol is a P2Y2-receptor agonist. It acts on P2Y2 receptors on the conjunctival epithelium and goblet cell membranes thereby increasing intracellular Ca ion concentration promoting fluid and mucin secretion. Pharmacokinetics: Metabolism: Rapidly metabolised into uridine-5'-monophosphate, uridine and uracil. |
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Chemical Structure
 Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 148197, Diquafosol. https://pubchem.ncbi.nlm.nih.gov/compound/Diquafosol. Accessed Oct. 28, 2024. |
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Storage
Store below 30°C.
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MIMS Class
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References
Brayfield A, Cadart C (eds). Diquafosol Tetrasodium. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 27/09/2024. Diquafosol. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 27/09/2024. Diquas Ophthalmic Solution 3% (Santen Pharma Malaysia Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 27/09/2024. Diquas/Diquas-S (Santen Philippines, Inc.). MIMS Philippines. http://www.mims.com/philippines. Accessed 27/09/2024.
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