Diprogenta Mechanism of Action

Pharmacotherapeutic Group: Topical corticosteroid and anti-infective in combination.
Pharmacology: Pharmacodynamics: Mechanism of Action: Betamethasone/Gentamicin (DIPROGENTA) Cream or Ointment combines the sustained anti-inflammatory, antipruritic and vasoconstrictive actions of betamethasone dipropionate with the wide-spectrum bactericidal antibiotic activity of gentamicin sulfate.
Pharmacodynamic Effects: Bacteria susceptible to gentamicin include sensitive strains of Staphylococcus aureus (coagulase positive, coagulase negative and some penicillinase-producing strains) and the gram-negative bacteria: Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Proteus vulgaris and Klebsiella pneumoniae.
Toxicology: Nonclinical Toxicology: The effect of subacute administration of Betamethasone/Gentamicin (DIPROGENTA) Ointment on both the intact and abraded skin of rabbits and guinea pigs was studied under the conditions of the study. No adverse effects were observed on the intact and abraded skin. No systemic effects were seen that could be attributed to percutaneous absorption of corticosteroids.
The anti-bacterial activity, toxicity, local and systemic tolerance, local anti-inflammatory activity and side effects of Betamethasone/Gentamicin (DIPROGENTA) Ointment was determined. Betamethasone/Gentamicin (DIPROGENTA) Ointment had potent anti-bacterial activity and marked local anti-inflammatory effects. It was non-toxic and had extremely good systemic tolerance. There was no evidence of undesirable side effects at the dosage and route recommended for clinical use.