Diosvein Mechanism of Action

Pharmacokinetics: Diosmin + Hesperidin has a unique and rigorously demonstrated mode of action, which enables it to fight simultaneously all the pathophysiological aspects of venous disease, affecting the veins, lymphatics, and microcirculation.
Veins: Diosmin + Hesperidin prolongs the vasoconstrictor effect of noradrenaline on the vein wall, even under warm and acidotic conditions, increasing venous tone, and therefore reducing venous capacitance, distensibility, and stasis. This increases the venous return and reduces venous hyperpressure present in patients suffering from chronic venous disease. At the macrocirculatory level, Diosmin + Hesperidin has been recently proven to protect the venous valves from leukocyte-induced inflammation and destruction, preventing the appearance of reflux, and therefore protecting against the progression of chronic venous disease toward complications.
Lymphatics: Diosmin + Hesperidin improves lymphatic drainage by increasing the frequency and intensity of lymphatic contractions, and by increasing the total number of functional lymphatic capillaries. Furthermore, Diosmin + Hesperidin decreases the diameter of lymphatic capillaries and the intralymphatic pressure.
Microcirculation: At the microcirculation level, Diosmin + Hesperidin reduces capillary hyperpermeability and increases capillary resistance by protecting the microcirculation from inflammatory damaging processes. Diosmin + Hesperidin reduces the expression of adhesion molecules on endothelial cells (ICAM1, VCAM1) and on leukocytes (L-selectin, VLA-4, CD 11b), and inhibits the adhesion, migration, and activation of leukocytes at the capillary level. This leads to a reduction in the release of inflammatory mediators, principally oxygen free radicals and prostaglandins (PGE2, PGF2a).
This protective and reinforcing action on the venous and lymphatic system, associated with the vasculoprotective effect on the macro- and the microcirculation, explains the restorative and protective efficacy of Diosmin + Hesperidin in chronic venous disease and hemorrhoidal disease, both of which are associated with perivascular inflammation and edema.