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Fluconazole should not be used in patients with known sensitivity to the drug, any of the inert ingredients, such as lactose, maize starch, colloidal silicon dioxide, magnesium stearate and sodium lauryl sulphate for fluconazole (Diflucan) capsules or sodium chloride for fluconazole (Diflucan) solution for injection, or to related azole compounds.
Coadministration of terfenadine is contraindicated in patients receiving fluconazole at multiple doses of 400 mg/day or higher based upon results of a multiple-dose interaction study. Coadministration of other drugs known to prolong the QT interval and which are metabolized via the enzyme CYP3A4 such as cisapride, astemizole, erythromycin, pimozide and quinidine are contraindicated in patients receiving fluconazole (see Precautions and Interactions).
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