Differin Drug Interactions

Absorption of adapalene through human skin is low (see Pharmacokinetics properties), and therefore interaction with systemic medications is unlikely.
There are no formal drug-drug interaction studies conducted with other medications which might be used cutaneously and concurrently with Adapalene (Differin) products.
Cutaneous antiacne treatments such as erythromycin (up to 4%) or clindamycin phosphate (1% as the base) solutions or benzoyl peroxide water-based gels (up to 10%) may be used in the morning with Adapalene (Differin) products used at night as there is no mutual degradation or cumulative irritation. However, other retinoids or drugs with a similar mode of action should not be used concurrently with Adapalene (Differin) products.
Adapalene (Differin) products are essentially stable to oxygen and light and is chemically non-reactive. Whilst extensive studies in animals and man have shown neither phototoxic nor photoallergic potential for Adapalene (Differin) products, the safety of using Adapalene (Differin) products during repeated exposure to sunlight or UV irradiation has not been established in either animals or man. Exposure to excessive sunlight or UV irradiation should be avoided.
Adapalene (Differin) products have a potential for mild local irritation, and therefore it is possible that concomitant use of peeling agents, abrasive cleansers, strong drying agents, astringents or irritant products (aromatic and alcoholic agents) may produce additive irritant effects.
Cream: There are no known interactions with other medications which might be used cutaneously and concurrently with Differin Cream; however, other retinoids or drugs with a similar mode of action should not be used concurrently with adapalene.
Adapalene is essentially stable to oxygen and light and is chemically non-reactive. Whilst extensive studies in animals and man have shown neither phototoxic nor photoallergic potential for adapalene, the safety of using adapalene during repeated exposure to sunlight or UV irradiation has not been established in either animals or man. Exposure to excessive sunlight or UV irradiation should be avoided.
Absorption of adapalene through human skin is low, and therefore interaction with systemic medications is unlikely. There is no evidence that the efficacy of oral drugs such as contraceptives and antibiotics is influenced by the cutaneous use of Differin Cream.
Differin Cream has a potential for mild local irritation, and therefore it is possible that concomitant use of peeling agents, astringents or irritant products may produce additive irritant effects. However, cutaneous antiacne treatments, e.g. erythromycin (up to 4%) or clindamycin phosphate (1% as the base) solutions or benzoyl peroxide water based gels up to 10%, may be used in the morning when Differin Cream is used at night as there is no mutual degradation or cumulative irritation.