Diclegis Dosage/Direction for Use

Posology: The recommended starting dose is two tablets at bedtime (Day 1). If this dose adequately controls symptoms the next day, the patient can continue taking two tablets at bedtime. However, if symptoms persist into the afternoon of Day 2, the patient must continue the usual dose of two tablets at bedtime (Day 2) and on Day 3 take three tablets (one tablet in the morning and two tablets at bedtime). If these three tablets do not adequately control symptoms on Day 3, the patient can take four tablets starting on Day 4 (one tablet in the morning, one tablet mid-afternoon and two tablets at bedtime).
The maximum recommended daily dose is four tablets (one in the morning, one in the mid-afternoon and two at bedtime).
Doxylamine succinate + Pyridoxine HCl (Diclegis) should be taken as a daily prescription and not on an as needed basis. Continued need for Doxylamine succinate + Pyridoxine HCl (Diclegis) should be reassessed as the pregnancy progresses. To prevent a sudden return of nausea and vomiting of pregnancy symptoms, a gradual tapering dose of Doxylamine succinate + Pyridoxine HCl (Diclegis) is recommended at the time of discontinuation.
Hepatic impairment: No pharmacokinetic studies have been conducted in hepatic impaired patients. Caution is however recommended due to potential for reduced metabolism, there is a possibility of dosage adjustment (see Precautions).
Renal impairment: No pharmacokinetic studies have been conducted in renal impaired patients. Caution is however recommended due to potential for metabolite accumulation, there is a possibility of dosage adjustment (see Precautions).
Paediatric population: Doxylamine succinate + Pyridoxine HCl (Diclegis) is not recommended for use in children under 18 years of age, due to lack of clinical data (see Pharmacology: Pharmacodynamics under Actions).
Method of administration: Oral use.
Doxylamine succinate + Pyridoxine HCl (Diclegis) should be administered on an empty stomach with a glass of water (see Interactions). The delayed-release tablets should be swallowed whole and should not be crushed, split or chewed.