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If the patient is allergic to loperamide or any ingredient in the product.
If it is for a child under 12 years old.
If the patient is pregnant or breastfeeding.
If the patient is constipated and also in whom constipation should be avoided (e.g., diarrhea resulting from infections).
If the abdomen is swollen or the patient has abdominal pain.
If the patient has acute dysentery which is characterized by blood in stools and high fever.
If the patient has pseudomembranous colitis (diarrhea associated with antibiotics), active ulcerative colitis, meningitis, or a history of liver disease.
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