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There is limited clinical experience with overdose of desvenlafaxine in humans. There is no known specific antidote for desvenlafaxine. Induction of vomiting is not recommended. Due to the moderate volume of distribution of this drug, it is unlikely that forced diuresis, dialysis, hemoperfusion and exchange transfusion are beneficial.
Treatment should consist of those general measures employed in the treatment of overdosage with any SSRI/IRNS. Ensure adequate airway, oxygenation and ventilation. Monitor cardiac rhythm and vital signs. General symptomatic and supportive measures are also recommended. Gastric lavage with a large-bore orogastric tube with appropriate protection of the airways, if necessary, may be indicated if performed soon after ingestion or in symptomatic patients. Activated charcoal should be administered.
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