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Antibiotic-associated pseudomembranous colitis, which may be fatal, develops during or weeks after therapy with clindamycin and is common in women and elderly. This is caused by necrotizing toxins secreted by Clostridium spp., particularly Clostridium. difficile.
Allergic rashes and urticarial, Steven-Johnson-like syndrome, anaphylaxis transient leucopenia, leucopenia (with agranulocytosis), eosinophilia, thrombocytopenia, erythema multiforme, exfoliative and vesiculobullous dermatitis, polyarthritis, abnormalities of liver function tests, overt jaundice and hepatic damage have been reported with the use of clindamycin.
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