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Pharmacology: Pharmacodynamics: Daflon exerts a dual action on the venous return system: at vein and venule level, it increases parietal tone and exerts an anti-stasis action; at the microcirculatory level, it reinforces capillary resistance and normalizes capillary permeability.
Pharmacokinetics: In humans, following oral administration of the medicinal product with carbon 14-labelled diosmin: excretion is essentially fecal and urinary excretion is on average 14% of the administered quantity, the elimination half-life is 11 hours, the product is highly metabolized as evidenced by the presence of various phenol acids in the urine.
Toxicology: Preclinical safety data: Non-clinical data reveal no special hazard for humans based on conventional studies of repeated dose toxicity, genotoxicity and toxicity to reproduction.
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