Cozin Mechanism of Action

Pharmacology: Pharmacodynamics: Mechanism of Action: Dibencozide is one of the active forms of Vitamin B12. Dibencozide increases the protein "efficiency coefficient" for example, the proportion of "bound nitrogen" for protein fabrication in the system evaluated to "consumed nitrogen" with food ingestion. The initial sign of effectiveness is manifested by a marked increase in appetite.
Thus, dibencozide facilitates optimum utilization of dietary protein intake, contributes to the formation and repair of body tissues and stimulates appetite.
Pharmacokinetics: Vitamin B12 substances bind to intrinsic factor, a glycoprotein secreted by the gastric mucosa, and are then actively absorbed from the gastrointestinal tract. Absorption is impaired in patients with an absence of intrinsic factor, with a malabsorption syndrome or with disease or abnormality of the gut, or after gastrectomy. Absorption from the gastrointestinal tract can also occur by passive diffusion; little of the vitamin present in food is absorbed in this manner although the process becomes increasingly important with larger amounts such as those used therapeutically. After intranasal dosage, peak plasma concentrations of cyanocobalamin have been reached in 1 to 2 hours. The bioavailability of the intranasal preparation is about 7 to 11% of that by intramuscular injection.