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Etoricoxib should be used with caution to patients with renal and hepatic impairment. It should not be used by pregnant and breastfeeding patients, patients with severe heart failure and those with active peptic ulcer.
Etoricoxib should not be taken with any other non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, diclofenac or pain-relieving doses of aspirin, as this may increase the risk of side effects on the stomach and intestines.
COX-2 inhibitors are not to be given to patients with allergy to NSAIDs and those with asthma.
Exercise caution when prescribing Selective COX-2 inhibitors in patients with ischemic heart disease and those with risk factors for heart disease; hypertension; hyperlipidemia, diabetes, smoking and patients with peripheral arterial disease.
Considering association between cardiovascular risk and exposure to COX-2 inhibitors, doctors are advised to use the lowest effective dose for the shortest duration of treatment.
Intake of COX-2 inhibitors should be stopped with appearance of skin rash and signs of hypersensitivity.
If not yet instituted, warning statement should include potential gastrointestinal (gastric and liver) and renal toxicities.
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