Coversyl Plus Dosage/Direction for Use

One Perindopril arginine + Indapamide (Coversyl Plus) film-coated tablet per day as a single dose, preferably to be taken in the morning, and before a meal.
Hepatic impairment: In severe hepatic impairment, treatment is contraindicated.
In patients with moderate hepatic impairment, no dose modification is required.
Method of administration: Oral use.
Missed Dose: It is important to take this medicine every day as regular treatment is more effective. However, if a dose of Perindopril arginine + Indapamide (Coversyl Plus) is forgotten, take the next dose at the usual time. Do not take a double dose to make up for a forgotten dose.
5 mg/1.25 mg: When possible, individual dose titration with the components is recommended. Perindopril arginine + Indapamide (Coversyl Plus) should be used when blood pressure is not adequately controlled on Perindopril arginine + Indapamide (Preterax) 2.5mg/625mcg film-coated tablet (where available). When clinically appropriate, direct change from monotherapy to Perindopril arginine + Indapamide (Coversyl Plus) film-coated tablet may be considered.
Elderly: Treatment should be initiated after considering blood pressure response and renal function.
Renal impairment: In severe renal impairment (creatinine clearance below 30 ml/min), treatment is contraindicated.
In patients with moderate renal impairment (creatinine clearance 30-60 ml/min), it is recommended to start treatment with the adequate dosage of the free combination.
In patients with creatinine clearance greater than or equal to 60 ml/min, no dose modification is required.
Usual medical follow-up will include frequent monitoring of creatinine and potassium.
Pediatric population: The safety and efficacy of perindopril arginine/indapamide in the pediatric population have not yet been established. No data are available.
Perindopril arginine + Indapamide (Coversyl Plus) should not be used in children and adolescents.
10 mg/2.5 mg: Elderly: In elderly, the plasma creatinine must be adjusted in relation to age, weight and gender. Elderly patients can be treated if renal function is normal and after considering blood pressure response.
Renal impairment: In severe and moderate renal impairment (creatinine clearance below 60 ml/min), treatment is contraindicated.
Usual medical follow-up will include frequent monitoring of creatinine and potassium.
Pediatric population: The safety and efficacy of Perindopril arginine + Indapamide (Coversyl Plus) in children and adolescents have not yet been established. No data are available. Perindopril arginine + Indapamide (Coversyl Plus) should not be used in children and adolescents.