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DORZOLAMIDE HCl + TIMOLOL MALEATE (COSOPT)/(Cosopt-S) is contraindicated in patients with: reactive airway disease, including bronchial asthma or a history of bronchial asthma, or severe chronic obstructive pulmonary disease; sinus bradycardia, sick sinus syndrome, sino‑atrial block, second or third degree atrioventricular block not controlled with pacemaker, overt cardiac failure, cardiogenic shock; hypersensitivity to one or both active substances or to any of the excipients.
The previously mentioned are based on the components and are not unique to the combination (see Description).
Cosopt-S: Severe renal impairment (CrCl <30 mL/min) or hyperchloraemic acidosis.
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