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Due to the presence of both components of the medicinal product, Clopidogrel bisulfate + Aspirin (CoPlavix) is contraindicated in case of: Hypersensitivity to the active substances or to any of the excipients; Severe hepatic impairment; Active pathological bleeding such as peptic ulcer or intracranial haemorrhage.
In addition, due to the presence of Aspirin, its use is also contraindicated in: Hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs) and syndrome of asthma, rhinitis, and nasal polyps; Patients with pre-existing mastocytosis, in whom the use of acetylsalicylic acid may induce severe hypersensitivity reactions (including circulatory shock with flushing, hypotension, tachycardia and vomiting); Severe renal impairment (creatinine clearance <30 ml/min); Third trimester of pregnancy (see Use in Pregnancy & Lactation).
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