Comfora

Relief of bladder pain or discomfort associated w/ interstitial cystitis.

Adult 300 mg/day taken as one (1) 100-mg cap tid.

Should be taken on an empty stomach: Take w/ water at least 1 hr before or 2 hr after meals.

Hypersensitivity. Do not use in patients who actively bleed due to weak anticoagulant effect.

Reassess response to treatment every 3 mth. Stop treatment in case no improvement is reached 6 mth after treatment initiation. Continue treatment chronically as long as response is maintained in responders. Eliminate other urologic disorders eg, UTI or bladder cancer. Evaluate patients undergoing invasive procedures or having signs/symptoms of underlying coagulopathy or other increased risk of bleeding (due to treatment w/ other medicinal products influencing coagulation eg, anticoagulants, heparin derivatives, thrombolytic or antiplatelet agents including ASA, or NSAIDs) for hemorrhagic events. Carefully monitor patients who have history of heparin or pentosan polysulfate Na-induced thrombocytopenia; w/ relevant hepatic or renal insufficiency. Retinal pigmentary changes w/ long-term use. Not recommended during pregnancy. Not to be used during breastfeeding. Safety & efficacy has not been established in childn & adolescent <18 yr.

Headache, dizziness & GI events like diarrhea, nausea, abdominal pain & rectal bleeding. Infections, flu; dyspepsia, enlarged abdomen, rectal hemorrhage; peripheral edema, alopecia; back pain; urinary frequency; asthenia, pelvic pain.

Evaluate patients who are concomitantly treated w/ anticoagulants, heparin derivatives, thrombolytic or antiplatelet agents including ASA, or NSAIDs for any hemorrhagic event to adapt the dose if needed.

Other Drugs Acting on the Genito-Urinary System

G04BX15 - pentosan polysulfate sodium ; Belongs to the class of other urologicals.

Rx