Combiflex Lipid Central/Combiflex Lipid Peri Adverse Reactions

The infusion may cause a rise in body temperature (incidence <3%) and, less frequently, shivering, chills and nausea/vomiting (incidence <1%). Transient increases in liver enzymes during intravenous nutrition have also been reported. As with all hypertonic solutions for infusion, thrombophlebitis may occur if peripheral veins are used.
Reports of the undesirable effects in conjunction with the included components are extremely rare. Hypersensitivity reactions (anaphylactic reaction, skin rash, urticaria), respiratory symptoms (e.g. tachypnea) and hyper/hypotension have been described. Haemolysis, reticulocytosis, abdominal pain, headache, nausea, vomiting, tiredness and priapism have been reported.
Lipid overload syndrome: An impaired capacity to eliminate lipid may lead to lipid overload syndrome. This may occur as a result of overdosage, but also at recommended rates of infusion, in association with a sudden change in the patient's clinical condition resulting in severe renal or hepatic impairment.
The lipid overload syndrome is characterized by hyperlipidaemia, fever, hepatosplenomegaly, anaemia, leucopenia, thrombocytopenia, coagulopathies and coma. These changes are invariably reversible on discontinuation of the lipid infusion.