Co-Zincretin 50/500/Co-Zincretin 50/1000/Co-Zincretin XR 100/1000 Dosage/Direction for Use

The dose of antihyperglycaemic therapy with Sitagliptin Phosphate + Metformin Hydrochloride should be individualised on the basis of the patient's current regimen, effectiveness, and tolerability while not exceeding the maximum recommended daily dose of 100 mg sitagliptin.
Co-Zincretin 50/1000: Adults with normal renal function (GFR ≥90 mL/min): For patients not adequately controlled on metformin alone: The usual starting dose should provide sitagliptin dosed as 50 mg twice daily (100 mg total daily dose) plus the dose of metformin already being taken.
For patients switching from co-administration of sitagliptin and metformin: Should be initiated at the dose of sitagliptin and metformin already being taken.
For patients inadequately controlled on dual combination therapy with the maximal tolerated dose of metformin and a sulphonylurea: The dose should provide sitagliptin dosed as 50 mg twice daily (100 mg total daily dose) and a dose of metformin similar to the dose already being taken. When sitagliptin and metformin is used in combination with a sulphonylurea, a lower dose of the sulphonylurea may be required to reduce the risk of hypoglycaemia.
For patients inadequately controlled on dual combination therapy with the maximal tolerated dose of metformin and a PPARγ agonist: The dose should provide sitagliptin dosed as 50 mg twice daily (100 mg total daily dose) and a dose of metformin similar to the dose already being taken.
For patients inadequately controlled on dual combination therapy with insulin and the maximal tolerated dose of metformin: The dose should provide sitagliptin dosed as 50 mg twice daily (100 mg total daily dose) and a dose of metformin similar to the dose already being taken. When sitagliptin and metformin is used in combination with insulin, a lower dose of insulin may be required to reduce the risk of hypoglycaemia.
All patients should continue their recommended diet with an adequate distribution of carbohydrate intake during the day.
Or as directed by physician.
Method of administration: For Oral Administration.