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Neostigmine should be used with caution in patients with epilepsy, bronchial asthma, bradycardia, recent coronary occlusion, vagotonia, hyperthyroidism, cardiac arrhythmias or peptic ulcer.
Neostigmine should not be administered to patients with peritonitis, mechanical obstruction of the intestinal or urinary tracts or doubtful bowel viability. Patients with a known sensitivity to neostigmine should not be treated with the drug.
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