Hypersensitivity to ciprofloxacin and other quinolone drugs or to any of preparation components; pregnancy, lactation. Simultaneous administration of ciprofloxacin and tizanidine, due to clinically significant side effects (arterial hypotension, drowsiness) associated with increased blood plasma tizanidine concentration. As the drug administration leads to the development of chondropathies and arthropathies, it should not be prescribed in children.