In severe over dosage with antihistamines the stomach should be emptied. Emetics may be tried if the patient is alert and there are no symptoms of toxicity but may be ineffective due to the antiemetic activity of the antihistamine. Activated charcoal this been given as saline laxatives especially if sustained-release preparations were involved. Convulsions may be controlled with diazepam, although it has been suggested that CNS depressants should be avoided. Central stimulants may increase the risk convulsions and their avoidance is advisable.